Noreen Ziegler, DVM, CNC
History of the Research

Influential scientists such, as Dr. Daniel Nixon of the Hollings Cancer Institute
(Medical University of South Carolina, USA), have been working with certain
micro-nutrients and their impact on human health.  Dr. Nixon’s most recent
work has been with raspberries and specifically the micronutrient ellagic acid
contained in the pulp and seeds.  His work with tissue cultures has shown that
cancer cells (of many types) exposed to ellagic acid levels corresponding to
specific amounts of eating fresh raspberries underwent a natural cell death.  
This is incredibly important news, because the amount of raspberries needed
to develop this level of ellagic acid was only one cup!

Dr. Nixon has also shown that human cervical cells infected with human
papilloma virus (HPV, warts) are also killed by the same concentration of
ellagic acid.  This is important because human papilloma viruses are
considered to be the main cause of cervical cancer.

Other scientist have found positive responses using ellagic acid in
researching many other conditions and disease:

  • Periodontal disease
  • Protection of the liver from toxic injury
  • Faster would healing
  • Radiation induced chromosomal damage
  • Slowing the spread of the HIV virus in the human body
  • Slowing the degenerative process of aging
  • Prevention of neural tube birth defects Neurodegenerative diseases
  • Diabetic retinopathy
I would like to call your attention to one of the most exciting new discoveries in
the treatment and cure for cancer.  It is not new.  These are the ellagitannins
contained in the Meeker variety of raspberry.  The following article “Berry
Good Health” written by Doctor Susan Thorpe-Vargas explains what cancer is
and how ellagitannins can be an effective treatment for this disease.

Dr. Vargas has written more than 70 feature articles in leading magazines
dealing with pesticides, genetics, nutrition, vaccines, therapies, preservatives,
arthritis, nutraceuticals, and poisoning.  These articles have been reprinted
nationally and internationally and have been translated into at least three
languages.  Dr. Vargas has a PhD in immunology from Oregon Health
Sciences and a Masters of Science in Biochemistry from Washington State

Berry Good Health
Susan Thorpe-Vargas Ph.D.

Multiple studies have discovered that phytonutrients found in raspberries can
protect us from cancer and can even shrink some types of cancer tumors.  
These substances can also act as an antibacterial and as an antiviral agent.  
Does this sound too good to be true?  One particular substance found in this
natural “medicine chest”, is a series of compounds called ellagitannins.  The
highest levels are found in raspberries,
but the ellagitannins are also in certain types of grapes, strawberries,
blackberries, blueberries and some nuts too.  Recent work (2001), published
by Dr. Gary Stoner at Ohio State University, showed that components in the
seeds and berry, but particularly ellagitannins, inhibited the initiation and
promotion/progression stages of esophageal cancer.  This is an extremely
important finding, considering the potential benefits.  In addition, edible
berries, including raspberries also inhibit angiogenesis.  This is a term used to
describe the development of blood vessels needed for tumor growth.

We do not as yet know all of the functions of the ellagitannins in terms of
cancer.  A study at Hollings Cancer Center, Medical University of South
Carolina has shown one of the ways they work is to “turn on” a normal cellular
process called apoptosis.  Apoptosis is “science speak” for something called
programmed cell death.  This natural cell death is just one of several ways our
body protects us from cancer.  As we age, cellular replication mistakes can
occur.  Cancer cells somehow become immune to the signals that cause cells
to self-destruct, so they become virtually immortal and reproduce indefinitely.

The disease with a thousand faces

Cancer is not just one disease but is the general name for more than 200
different types of malignancies.  Cancers are classified by the tissue type from
which they arise.  To illustrate:

  • osteosarcoma-bone cancer
  • melanoma-skin cancer
  • lymphoma-cancer of lymph nodes
  • leukemia-blood cancer

Every cellular type has its own form of cancer.  The one thing all cancers
share in common is uncontrolled growth.  Cancer occurs when cells lose
control over critical checkpoints during the process of one cell
splitting and becoming two cells.  This control over cellular replication is in the
hands of several specific types of genes.

Two classes of genes are suspected of being associated with the occurrence
of cancer.  A mutation in a tumor suppressor gene is like having faulty brakes
in your car.  Just as their name implies, tumor suppressor genes function by
making sure there are no mistakes in the genes that are replicated prior to
one cell becoming two.  In this “quality control” process, if errors are detected,
the cell is instructed not to divide.  Thus, tumor suppressor genes put the
brakes of cellular division.  The other class of genes thought to be involved
with preventing cancer is called proto-oncogenes.  Researchers have found
that these genes “code” for proteins involved in mechanisms that regulate the
social behavior of cells.  Signals from those cells in the immediate
environment induce their neighbors to divide, differentiate and even undergo
apoptosis.  So this type of gene is involved in promoting the normal growth
and division of cells and could be likened to your car’s accelerator.  A change
in the genetic message – a mutation, can turn the proto-
Oncogene into an oncogene and cause your accelerator to become stuck,
thus initiating “runaway” cellular replication.  Nevertheless, there seems to be
no pattern to these mutations.  What is so frustrating for both researchers
and clinicians alike is that different combinations of mutations are found in
different types of cancer and even in cancers of supposedly the same type in
different patients.  What is most important to remember is that cancer begins
as a single abnormal cell that begins to multiply out of control.

So, what causes most mutations?

We live is a polluted environment.  For instance, the out gassing from asphalt
on a hot summer day produces the deadly carcinogen benzo(a)pyrene, the
same chemical found on meat that has been charcoal broiled.  This is just but
one example.  Exposure to such chemicals in the environment can cause the
mutations in our genetic material that leads to cancer.  Even normal metabolic
processes like breathing and exercise produce free radicals that can wreak
havoc on our cellular DNA.  We can protect ourselves from mutations caused
by environmental toxins and free radicals by taking antioxidants.  Guess
what?  Ellagitannins are also very good antioxidants and chemoprotective
agents.  Researchers at Wayne State University have a theory about how
ellagitannins might work.  The liver produces enzymes that rid the body of
toxins.  These enzymes break down or chemically change toxic substances we
ingest or inhale so that they can be excreted.  During this detox process, the
breakdown products, called metabolites, are frequently more damaging than
the original substance.  It appears that ellagitannins are able to safeguard the
liver from damage caused be these breakdown products.  Another theory held
by some investigators is that ellagitannins are able to protect our genetic
material from certain types of chemical reactions that lead to misreading of
damaged DNA.

Why does chemotherapy and radiation eventually stop working?

It is becoming clear that normal therapeutic cancer treatment works by turning
on apoptosis.  We used to think that chemotherapy and radiation killed rapidly
dividing cells, which is why these procedures were able to shrink tumors.  
However, at some point these treatments begin to lose their effectiveness.  
Why is that?  Scott Lowe, a research scientist at Cold Spring Harbor
Laboratory may have found the answer.  Instead of killing these cells,
chemotherapy and radiation damage their cellular DNA.  This alerts the cell
watchdogs that control the cell cycle that something is wrong and tells the cell
to stop dividing or to commit suicide.  Therefore, chemotherapy and radiation
act somewhat like a “vaccination” that works by helping the body help itself.  
The evidence for Dr. Lowe’s theory is pretty convincing, because when these
treatments start to fail, researchers have found that the genes that control
apoptosis are no longer functioning.

Why don’t ellagitannins induce normal cells to commit suicide?

As we know, cancer cells become immortal; this means that they are able to
replicate themselves after something called the Hayflick limit has been
reached.  The Hayflick limit is the number of “allowed” cellular replications.  
Each cell type has its own limit.  Human cancer studies show that mutations in
the tumor suppressor gene called p53 account for many of the tumors found.  
One of the functions of this gene is that it normally prevents cells with
damaged DNA from proceeding through the cell cycle.  The presence of the
protein product encoded by p 53 turns on the waf-1 gene.  The waf-1 gene
produces a protein that normally inhibits the activity of several similar cellular
proteins called kinases.  These proteins are involved in stopping cell cycle
progression.  A mutation in either the p53 or waf-1 gene can cause the loss of
that “emergency brake” function and allow uncontrolled growth.  However,
only “damaged” cells are induced   to commit suicide and so normal cells are
not affected.

An Antibacterial and an Antiviral agent

Ellagitannins can act as antibacterial agents and as antiviral agents too, and
now we know how.  Think of the genetic material of bacteria as a rubber band
that is all twisted up.  In order to replicate, the DNA must untwist itself through
a process requiring the enzyme gyrase.  Ellagitannins inhibit gyrase activity so
replication of the bacterial DNA is restricted.  Importantly, bacteria cannot
easily become resistant to this type of antibacterial action.  Resistance to
antibiotics has become a real concern to the international medical
community.  A federal government task force noted that antibiotic resistance
was “a growing menace to all people” but children, the elderly and those with
weakened immune systems are especially at risk.  Besides its antibacterial
action, ellagitannins have antiviral activity also.  Viruses do not have the
ability to replicate themselves.  Instead that must “hijack” the host cell and
insert their own DNA into the host cell genome.  This requires an enzyme
called integrase and the ellagitannins inhibit this enzyme also.

Citizen: Heal Thyself.  (With apologies to Mr. Hippocrates)

People are turning to alternative forms of medical treatment and prevention.  
Not only is the medical delivery system failing but, our costs for heath services
are rising at an astronomical rate.  What this means for the medical consumer
is that we need to be more responsible for our own health.  We need to look
at prevention instead of always looking to health care providers to “fix” what
exposure to a toxic environment and/or years of unhealthy lifestyle practices
have wrought.  The quality of medical care is uneven at best.  Too often, our
insurance providers do not cover necessary tests and procedures, especially
those of a preventative nature.  However, we can become involved in our own
health care.  A diet rich in fresh fruits and vegetables is a good start towards
preventing disease.  Unfortunately, current test show that our soil is severely
lacking in many minerals or electrolytes and other components that are
essential for proper nutrition.  It is necessary to sometimes take supplements
as it may not be physically or economically
possible to eat enough food to get the proper nutrition.  In addition, the cost
of fresh fruits and vegetables can be prohibitive.  For instance, unless you
grow your own raspberries, the cost of the American Cancer Institute’s
recommended daily bowl of the whole berries could run as high as $300 a
month.  Not only that, but research has shown that the ellagitannin content is
much higher in the seeds then in the fruit.  In addition, the powdered seed
may be much more bioavailable then the whole fruit, especially so for the
short carnivorous gut of the cat or dog.  So nutraceutical supplements appear
to be the answer.  Raspberry seeds contain many more times the
ellagitannins than the fruit at one-tenth the cost.  It’s your choice, whatever
form you may decide to use – the take home message is: “Eat your

Remu International has established itself as one of the leading suppliers of
Meeker Raspberry Capsules, Meeker Raspberry Powder and Meeker
Raspberry Skin Cream to consumers, web suppliers, pet owners, health food
stores and cancer clinics worldwide.  Raspberries contain one of the most
powerful antioxidants known – a series of ellagitannins that are converted into
ellagic acid in the body.  Raspberry ellagitannins are one of very few fruits
that have been clinically shown to be transformed into beneficial levels of
ellagic acid in the body.

The ellagitannin content of red raspberry seeds varies dramatically with the
variety of the berry.  The highest levels of ellagitannins are found in the
Meeker variety of raspberry.  Remu has selected a processor who guarantees
us greater than 85% Meeker raspberry content and is willing to actively
control their raw material stream to satisfy our strict nutraceutical
requirements. Remu processes the seed into maximum bioavailable flour
which frees the ellagitannis for immediate adsorption and transformation into
ellagic acid in the body.  Remu’s Meeker Variety Raspberry Seed products
contain the highest amount of ellagitannins available in nature per dollar
spent.  There has been much research into ellagic acid, its value as a
potential anti oxidant and its value in fighting cancer is widely accepted.  
Ellagic acid has been found to inhibit the promotion and progression of
esophageal, breast and prostate cancer and we are collecting many
testimonials that show that it is equally effective with many other types of
cancer including skin cancer.

This information is not intended to take place of medical advice.  You are advised to
consult your medical doctor or other qualified health care professional regarding treatment
of your medical conditions.